Imaging LDL Receptor Oligomerization during Endocytosis Using a Co-internalization Assay

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Oligomerization and Endocytosis of the α-Factor Receptor: A Dissertation

Factor receptors from Saccharomyces cerevisiae are G-protein-coupled receptors containing seven transmembrane segments. The abilty of a-factor receptors to form oligomeric complexes with each other and with other proteins was investigated. Both in vivo and in vitro evidence was obtained that suggests homo-oligomerization of receptors in the plasma membrane. When the membranes from cells coexpre...

متن کامل

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.

PATHWAYS OF RECEPTOR-MEDIATED ENDOCYTOSIS ....................................................................... 3 Entry Into Coated Pits ................................................................................................................... 3 Intracellular Routes ..........................................................................................................................

متن کامل

Internalization of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis.

Several studies have suggested that chondrocytes must have the capacity to internalize and degrade extracellular hyaluronan. In the present study we show direct evidence that hyaluronan is, in fact, endocytosed by chondrocytes and that the endocytosis is mediated via cell surface CD44/hyaluronan receptors. Cultures of bovine articular chondrocytes as well as rat chondrosarcoma chondrocytes were...

متن کامل

IRGM1 regulates oxidized LDL uptake by macrophage via actin-dependent receptor internalization during atherosclerosis

Macrophage derived foam cells are actively involved in the initial phase of atherosclerosis. Uptake of modified lipoprotein such as oxidized LDL (oxLDL) is a critical step for foam cell formation. CD36 is the major receptor mediating oxLDL uptake by macrophage. However, the molecular mechanism underlying CD36 mediated oxLDL uptake remains unclear. Here we reported that IRGM1 (IRGM in human), a ...

متن کامل

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)- dependent internalization of the urokinase receptor

The GPI-anchored urokinase plasminogen activator receptor (uPAR) does not internalize free urokinase (uPA). On the contrary, uPAR-bound complexes of uPA with its serpin inhibitors PAI-1 (plasminogen activator inhibitor type-1) or PN-1 (protease nexin-1) are readily internalized in several cell types. Here we address the question whether uPAR is internalized as well upon binding of uPA-serpin co...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: ACS Chemical Biology

سال: 2011

ISSN: 1554-8929,1554-8937

DOI: 10.1021/cb100361k